If VueScan still doesn't see your scanner, go into 'System Preferences', 'Accounts', then 'Startup Items'. If you're using the Ratoc USB->SCSI adapter, set up the adapter with the Ratoc utility to 'Mass Storage' mode.

Try setting the time between the power on and the SCSI bus reset to 40. If you're using a Ratoc Firewire-SCSI adapter, you may need to configure one of the options. If you're using a scanner that isn't supported by VueScan and you're using Mac OS X 10.10 or earlier, try installing TWAINBridge.app. If VueScan is crashing, try a newer USB cable and/or a different USB port. If it doesn't, try powering off the computer, powering off the scanner, powering on the scanner and then powering on the computer. If VueScan doesn't see your scanner on Mac OS X, first make sure that 'About This Mac' (in the Apple menu) in the USB devices section can see the scanner. It works fine but now whenever I need to scan my comic pages, I would have to go to the other room to do it. I had to end up hooking my scanner to a PC that my family has in another room in the house and I was able to download a driver for it since there's one for my scanner.

The next comparable scanner I can find at this size is this one: The fact that it isn't supported in OS Catalina is actually a nightmare. I work from home as a freelance artist and I use my scanner daily.

I've emailed Vuescan and they replied rather quickly to tell me they have no plans to support this hardware.

Vuescan for catalina